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Immediately following treatment with psilocybin, patients reported a decrease in depressive symptoms, such as improvements in mood and stress relief.

MRI imaging revealed reduced blood flow in areas of the brain, including the amygdala, a small, almond-shaped region of the brain known to be involved in processing emotional responses, stress and fear.

The authors believe the findings provide a new window into what happens in the brains of people after they have ‘come down’ from a psychedelic, with an initial disintegration of brain networks during the drug ‘trip’ followed by a re-integration afterwards.

Magic mushrooms 'reboot' brain in depressed people – study | Science | The Guardian
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